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Role of lubricin and boundary lubrication in the

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The role of lubricin in the mechanical behavior of .

Request PDF on ResearchGate | The role of lubricin in the mechanical behavior of synovial fluid | Synovial fluid is a semidilute hyaluronate (HA) polymer solution, the rheology of which depends on ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos

Lubricin, a mucinous glycoprotein encoded by the PRG4 gene, provides boundary lubrication in articular joints. Joint friction is elevated and accompanied by accelerated cartilage damage in humans and mice that have genetic deficiency of lubricin.

Transcription, Translation, and Function of Lubricin, a .

Lubricin plays a critical role as a boundary lubricant in articulating joints. 1-4 This amphiphilic glycoprotein, which is also called superficial zone protein, ... Boundary lubrication may also be dominant at the cornea–contact lens interface where there is a relative lack of aqueous tear.

The role of lubricin in the mechanical behavior of .

Abstract Synovial fluid is a semidilute hyaluronate (HA) polymer solution, the rheology of which depends on HA-protein interactions, and lubricin is a HA-binding protein found in synovial fluid and at cartilage surfaces, where it contributes to boundary lubrication under load.

The role of lubricin in the mechanical behavior of .

The role of lubricin in the mechanical behavior of synovial fluid. Jay G.D., Torres J.R., Warman M.L., Laderer M.C., Breuer K.S. Synovial fluid is a semidilute hyaluronate (HA) polymer solution, the rheology of which depends on HA-protein interactions, and lubricin is a HA-binding protein found in synovial fluid and at cartilage surfaces, where it contributes to boundary lubrication under load.

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Kimberly A. Wallera, Ling X. Zhangb, Khaled A. Elsaidc, Braden C. Fleminga,d,e, Matthew L. Warmanf,g, and Gregory D. Jaya,b,h,1 aCenter for Biomedical Engineering and the School of Engineering, Brown University, Providence, RI 02912; bEmergency Medicine Research Laboratory, Department of Emergency Medicine ...

The biology of Lubricin: Near frictionless joint motion .

Lubricin is a surface-active mucinous glycoprotein secreted in the synovial joint that plays an important role in cartilage integrity. In healthy joints, lubricin molecules coat the cartilage surface, providing boundary lubrication and preventing cell and protein adhesion.

Role of lubricin and boundary lubrication in the .

The contribution of boundary lubrication may be dictated by factors such as surface chemistry, roughness [16], and the adsorption of lubricating molecules, such as lubricin [14,[17][18][19].

Role of lubricin and boundary lubrication in the .

Title: Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis: Authors: Waller, K. A.; Zhang, L. X.; Elsaid, K. A.; Fleming, B. C ...

The role of lubricin in normal and pathological joint tissue: a contemporary revi

The aim of this article was to critically review the literature about lubricin and its involvement in normal and pathological joint tissue. In particular, our research focussed on new therapeutic approaches for the treatment of osteoarthritis related to lubricin. We reviewed the literature regarding lubricin expression.

Full-Length Recombinant Human Proteoglycan 4 Interacts .

Abstract. Proteoglycan 4 (PRG4) is a mucin-like glycoprotein present in synovial fluid and at the surface of articular cartilage. The objectives of this study were to (1) assess the articular cartilage surface adsorption and in vitro cartilage boundary lubricating ability of full-length recombinant human PRG4 (rhPRG4), and (2) cartilage boundary lubricating ability of purified rhPRG4, both ...

Galectin-3 Binds to Lubricin and Reinforces the .

Effective boundary lubrication by lubricin is dependent upon both its ability to adsorb to articular cartilage 11,12 and the presence of O-linked β(1–3)Gal-GalNAc oligosaccharides 13; however ...

Full-Length Recombinant Human Proteoglycan 4 Interacts .

Abstract. Proteoglycan 4 (PRG4) is a mucin-like glycoprotein present in synovial fluid and at the surface of articular cartilage. The objectives of this study were to (1) assess the articular cartilage surface adsorption and in vitro cartilage boundary lubricating ability of full-length recombinant human PRG4 (rhPRG4), and (2) cartilage boundary lubricating ability of purified rhPRG4, both ...

Boundary Lubrication - an overview | ScienceDirect Topi

Boundary lubrication involves a single monolayer of lubricant molecules, which are absorbed onto each of the bearing surfaces. This avoids surface wear by impeding the direct contact of surfaces (Hsu and Gates, 2000). The synovial fluid constituent responsible for the boundary lubrication is a specific glycoprotein, termed ‘lubricin’.

The role of lubricin in the mechanical behavior of .

Synovial fluid is a semidilute hyaluronate (HA) polymer solution, the rheology of which depends on HA–protein interactions, and lubricin is a HA-binding protein found in synovial fluid and at cartilage surfaces, where it contributes to boundary lubrication under load.

Full-Length Recombinant Human Proteoglycan 4 Interacts .

Abstract. Proteoglycan 4 (PRG4) is a mucin-like glycoprotein present in synovial fluid and at the surface of articular cartilage. The objectives of this study were to (1) assess the articular cartilage surface adsorption and in vitro cartilage boundary lubricating ability of full-length recombinant human PRG4 (rhPRG4), and (2) cartilage boundary lubricating ability of purified rhPRG4, both ...

Role of lubricin and boundary lubrication in the .

Lubricin, a mucinous glycoprotein produced by synovial cells and superficial zone chondrocytes (11, 14), provides lubrication in the boundary mode . Boundary lubrication dominates during periods of high load and low velocity, when the lubricant film layer is thinner than the surface roughness .

The role of lubricin in normal and pathological joint .

of lubricin, including lubrication and cytoprotection. Lubricin plays an important role in articular joint physiology, and the loss of accumu-lation of lubricin may be a factor in the pathology of osteoarthritis (OA) (Figure 1). Therefore, a recent study8 demonstrated that recombi-nant lubricin has a role in chondro-protection in an animal OA model

Lubricin: a novel potential biotherapeutic approaches for .

Therefore, a treatment with lubricin which would protect cartilage in vivo would be desirable. This article reviews recent findings with regard to the possible role of lubricin in the progression of OA, and further discusses lubricin as a novel potential biotherapeutic approaches for the treatment of OA.

Role of lubricin and boundary lubrication in the .

Osteoarthritis is a complex disease involving the mechanical breakdown of articular cartilage in the presence of altered joint mechanics and chondrocyte death, but the connection between these factors is not well established. Lubricin, a mucinous glycoprotein encoded by the PRG4 gene, provides boundary lubrication in articular joints. Joint friction is elevated and accompanied by accelerated ...